Bleeding Time in Atypical von Willebrand’s Disease
نویسندگان
چکیده
منابع مشابه
Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease.
We studied 17 patients with moderate to mild type I von Willebrand's disease (vWd) and correlated the bleeding time with the plasma von Willebrand factor antigen (vWf Ag), the plasma vWf activity (ristocetin cofactor), the platelet vWf Ag, and the platelet vWf activity. We found an excellent correlation between the bleeding time and the platelet vWf activity and, to a lesser extent, between the...
متن کاملGastrointestinal angiodysplasia and bleeding in von Willebrand disease.
Von Willebrand disease (VWD), the most common genetic bleeding disorder, is characterised by a quantitative or qualitative defect of von Willebrand factor (VWF). Patients with VWD suffer from mucocutaneous bleeding, of severity usually proportional to the degree of VWF defect. In particular, gastrointestinal bleeding associated with angiodysplasia is often a severe symptom of difficult manageme...
متن کاملThe Prevalence of von Willebrand Disease and Significance of in Vitro Bleeding Time (PFA-100) in von Willebrand Disease Screening in the İzmir Region
OBJECTIVE von Willebrand disease (vWD) is the most common hereditary bleeding disorder. The purpose of this investigation was to determine the prevalence of vWD among adolescents in İzmir and to assess the sensitivity and specificity of PFA-100 as a screening method in detecting this disease. MATERIAL AND METHODS Our study was conducted on adolescents in the city of İzmir between October 2006...
متن کاملEffects of Magnesium Sulfate on Bleeding Time in Premature Labor
Background: Several studies have shown that administration of magnesium sulfate prolongs the bleeding time. Objective: To investigate such effects in pregnant women in Shiraz, southern Iran. Methods:This study was conducted on 30 pregnant women aged between 18 and 32 yrs, with a gestational age of 20 to 37 weeks, who presented to Hafez and Zeynabiyeh Emergency Units affiliated to Shiraz Univer...
متن کاملShear stress activation of platelet glycoprotein IIb/IIIa plus von Willebrand factor causes aggregation: filter blockage and the long bleeding time in von Willebrand's disease.
The article explores the finding that high shear alone applied to normal, native blood results in platelet aggregation. A filter with tortuous capillary-sized channels permits a study of the effect of shearing forces at different pressures. Native, heparinized, citrated and EDTA blood and platelet-rich plasma (PRP) were forced through the filter. Normal and von Willebrand's blood were studied, ...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 1984
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000206430